Mr Ho is the Founder and Executive Chairman of Banyan Group and Laguna Resorts and Hotels, and Executive Chairman of Thai Wah Public Company. All three family-owned companies are listed in Singapore and Thailand.

He was the founding Chairman of Singapore Management University (SMU) and has chaired Singapore Power and MediaCorp Singapore. He has also served on the boards of Standard Chartered Bank, Diageo, Singapore Airlines and GIC. Among the various awards Mr Ho has received are the London Business School Entrepreneurship Award, CEO of the Year at the Singapore Corporate Awards, CNBC Travel Business Leader Award, and Distinguished Alumnus Award from the National University of Singapore. He has also won Lifetime Achievement Awards from the American Creativity Association, China Hotel Investment Summit and Australia Hotel Investment Summit. Honoured for his contributions to the hotel industry in the Asia Pacific region and globally, Mr Ho is the only two-time recipient of the Innovation Award (2003) and Lifetime Achievement Award (2019) from Hotel Investment Conference Asia Pacific (HICAP) in its 30-year existence. Most recently, Mr Ho received the Outstanding Contribution award at AHEAD Asia 2024.

For his services to the country, the Singapore Government awarded him the Meritorious Service Medal and Distinguished Service Order. Mr Ho has also been conferred honorary doctorates by Johnson & Wales University, Hong Kong Poly University and Singapore Management University.